Recent Advances in Wearable Transdermal Delivery Systems

被引：144
|
作者：
Amjadi, Morteza [1 ,2 ]
Sheykhansari, Sahar [1 ]
Nelson, Bradley J. [2 ]
Sitti, Metin [1 ]
机构：
[1] Max Planck Inst Intelligent Syst, Phys Intelligence Dept, D-70569 Stuttgart, Germany
[2] ETH, Dept Mech & Proc Engn, CH-8092 Zurich, Switzerland
来源：
ADVANCED MATERIALS | 2018年 / 30卷 / 07期
关键词：
drug carriers; multifunctional wearable devices; stimuli-responsive materials; transdermal delivery; wearable medical systems; FORMING MICRONEEDLE ARRAYS; REDUCED GRAPHENE OXIDE; DRUG-DELIVERY; PRESSURE SENSORS; RESPONSIVE NANOCARRIERS; COMPOSITE MICRONEEDLES; NONINVASIVE DELIVERY; POLYMER MICRONEEDLES; SENSITIVE VESICLES; TEMPERATURE-SENSOR;
D O I：
10.1002/adma.201704530
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Wearable transdermal delivery systems have recently received tremendous attention due to their noninvasive, convenient, and prolonged administration of pharmacological agents. Here, the material prospects, fabrication processes, and drug-release mechanisms of these types of therapeutic delivery systems are critically reviewed. The latest progress in the development of multifunctional wearable devices capable of closed-loop sensation and drug delivery is also discussed. This survey reveals that wearable transdermal delivery has already made an impact in diverse healthcare applications, while several grand challenges remain.
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页数：19
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