Genetic manipulation of schistosomes - progress with integration competent vectors

被引：13

作者：

Suttiprapa, Sutas

Rinaldi, Gabriel ^{[2
]}

Brindley, Paul J. ^{[1
]}

机构：

[1] George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Sch Med & Hlth Sci, Washington, DC 20037 USA

[2] Univ Republica, UDELAR, Fac Med, Dept Genet, Montevideo 11800, Uruguay

来源：

PARASITOLOGY | 2012年 / 139卷 / 05期

关键词：

Schistosomes; genetic manipulation; transgenesis; chromosome integration; germ line; retrovirus; murine leukaemia virus; pseudotyped gammaretrovirus; transposon; piggy Bac; SHORT HAIRPIN RNAS; PLASMODIUM-FALCIPARUM; BLOOD FLUKE; BIOLISTIC TRANSFORMATION; REPORTER TRANSGENES; IN-VITRO; MANSONI; EXPRESSION; INTERFERENCE; VIRUS;

D O I：

10.1017/S003118201100134X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Draft genome sequences for Schistosoma japonicum and S. mansoni are now available. The schistosome genome encodes similar to 13000 protein-encoding genes for which the functions of few are well understood. Nonetheless, the new genes represent potential intervention targets, and molecular tools are being developed to determine their importance. Over the past 15 years, noteworthy progress has been achieved towards development of tools for gene manipulation and transgenesis of schistosomes. A brief history of genetic manipulation is presented, along with a review of the field with emphasis on reports of integration of transgenes into schistosome chromosomes.

引用

页码：641 / 650

页数：10

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