Investigating potential physicochemical errors in polymer gel dosimeters

被引：16
|
作者：
Sedaghat, Mahbod [1 ]
Bujold, Rachel [2 ]
Lepage, Martin [1 ]
机构：
[1] Univ Sherbrooke, Ctr Imagerie Mol Sherbrooke, Dept Med Nucl & Radiobiol, Sherbrooke, PQ J1K 2R1, Canada
[2] CHU Sherbrooke, Serv Radio Oncol, Sherbrooke, PQ J1H 5N4, Canada
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2011年 / 56卷 / 18期
基金：
加拿大自然科学与工程研究理事会;
关键词：
DOSE DELIVERY ACCURACY; ACID-BASED GEL; POLYACRYLAMIDE-GEL; RADICAL POLYMERIZATION; N-ISOPROPYLACRYLAMIDE; PHOSPHONIUM CHLORIDE; POTASSIUM PERSULFATE; RADIATION-DOSIMETRY; TEMPERATURE; ACRYLAMIDE;
D O I：
10.1088/0031-9155/56/18/019
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Measurement errors in polymer gel dosimetry can originate either during irradiation or scanning. One concern related to the exothermic nature of polymerization reaction was that the heat released in polymer gel dosimeters during irradiation modifies their dose response. In this paper, the effect of heat released from the exothermal polymerization reaction on the dose response of a number of dosimeters was studied. In addition, we investigated whether heat-generated geometric distortion existed in newly proposed gel dosimeters that contain highly thermoresponsive polymers. Our results suggest that despite a significant internal temperature increase in some gel compositions, their dose responses are not affected when oxygen is well expelled mechanically from the gel mixture. We also report on significant pre-irradiation instability in some recently developed polymer gel dosimeters but that geometric distortions were not observed. Data obtained by a set of small calibration vials are compared to those obtained from larger phantoms, and potential physicochemical causes of deviations between them are identified.
引用
收藏
页码：6083 / 6107
页数：25
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