Connective tissue growth factor (CTGF) in age-related vascular pathologies

被引：53
|
作者：
Ungvari, Zoltan [1 ,2 ,3 ,4 ]
Valcarcel-Ares, Marta Noa [1 ,2 ]
Tarantini, Stefano [1 ,2 ]
Yabluchanskiy, Andriy [1 ,2 ]
Fulop, Gabor A. [1 ,2 ,5 ]
Kiss, Tamas [1 ,3 ,4 ]
Csiszar, Anna [1 ,2 ,3 ,4 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, 975 N E 10th St, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Translat Gerosci Lab, Oklahoma City, OK USA
[3] Univ Szeged, Fac Med, Dept Med Phys & Informat, Szeged, Hungary
[4] Univ Szeged, Fac Sci & Informat, Szeged, Hungary
[5] Univ Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary
来源：
GEROSCIENCE | 2017年 / 39卷 / 5-6期
关键词：
CTGF; Extracellular matrix; Cerebromicrovascular; Vascular aging; CEREBROMICROVASCULAR ENDOTHELIAL-CELLS; IGF-1; DEFICIENCY; OXIDATIVE STRESS; CYTOMEGALOVIRUS-INFECTION; CEREBRAL MICROHEMORRHAGES; ATHEROSCLEROTIC PLAQUES; MYOCARDIAL FIBROSIS; ELEVATED EXPRESSION; INDUCED OBESITY; MICE;
D O I：
10.1007/s11357-017-9995-5
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Connective tissue growth factor (CTGF, also known as CCN2) is a matricellular protein expressed in the vascular wall, which regulates diverse cellular functions including cell adhesion, matrix production, structural remodeling, angiogenesis, and cell proliferation and differentiation. CTGF is principally regulated at the level of transcription and is induced by mechanical stresses and a number of cytokines and growth factors, including TGF beta. In this mini-review, the role of age-related dysregulation of CTGF signaling and its role in a range of macro-and microvascular pathologies, including pathogenesis of aorta aneurysms, atherogenesis, and diabetic retinopathy, are discussed. A potential role of CTGF and TGF beta in regulation and non-cell autonomous propagation of cellular senescence is also discussed.
引用
收藏
页码：491 / 498
页数：8
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