Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension

被引：0

作者：

Iijima, Junko ^{[1
]}

Hoshi, Kyoka ^{[1
]}

Ito, Hiromi ^{[1
]}

Kanno, Mayumi ^{[1
,9
]}

Murakami, Yuta ^{[2
]}

Takahashi, Koichi ^{[5
]}

Matsumoto, Kana ^{[6
]}

Yamaguchi, Yoshiki ^{[6
,10
]}

Nakajima, Madoka ^{[7
]}

Miyajima, Masakazu ^{[7
]}

Arai, Hajime ^{[7
]}

Kanai, Mitsuyasu ^{[8
]}

Kitazume, Shinobu ^{[3
]}

Honda, Takashi ^{[4
,9
]}

Hashimoto, Yasuhiro ^{[1
,9
]}

机构：

[1] Fukushima Med Univ, Dept Biochem, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan

[2] Fukushima Med Univ, Dept Neurosurg, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan

[3] Fukushima Med Univ, Preparing Sect, Sch Hlth Sci, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan

[4] Fukushima Med Univ, Human Life Sci, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan

[5] Sanno Hosp, Dept Neurosurg, Minato Ku, 8-10-16 Akasaka, Tokyo 1070052, Japan

[6] RIKEN, Syst Glycobiol Res Grp, Struct Glycobiol Team, Global Res Cluster, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[7] Juntendo Univ, Dept Neurosurg, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan

[8] Mihara Mem Hosp, Div Neurol, Isezaki City, Gunma 3720006, Japan

[9] Fukushima Med Univ, Dept Forens Med, Sch Med, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan

[10] Tohoku Med & Pharmaceut Univ, Lab Pharmaceut Phys Chem, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan

来源：

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE | 2021年 / 67卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

chronic subdural hematoma (CSDH); enzyme-linked immunosorbent assay (ELISA); spontaneous intracranial hypotension (SIH); transferrin (Tf); DIAGNOSTIC-CRITERIA; N-GLYCAN; CSF; LEAKS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30% of patients do not show typical morphology and clinical test results. We previously reported that CSF contains transferrin (Tf) isoforms: "brain-type" Tf derived from the choroid plexus and "serum-type" Tf derived from blood. We showed that both isoforms increased in the CSF of patients with SIH by Western blotting. In the present study, we demonstrate that conventional ELISA for quantifying total Tf is useful for diagnosing SIH more accurately than Western blotting. In addition, SIR with chronic subdural hematoma (CSDH) was also accurately diagnosed. Total Tf in the CSF can serve as a useful biomarker for diagnosing Sill with or without CSDH.

引用

页码：64 / 70

页数：7

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