Caenorhabditis elegans germ line:: A model for stem cell biology

被引：72
|
作者：
Hubbard, E. Jane Albert [1 ]
机构：
[1] NYU, Helen I & Martin S Kimmel Ctr Stem Cell Biol, Sch Med Dev Genet, Skirball Inst Biomol Med, New York, NY 10016 USA
来源：
DEVELOPMENTAL DYNAMICS | 2007年 / 236卷 / 12期
关键词：
c; elegans; germ line; stem cell; renewal; niche; Notch;
D O I：
10.1002/dvdy.21335
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Like many stem cell systems, the Caenorhabditis elegans germ line contains a self-renewing germ cell population that is maintained by a niche. Although the exact cellular mechanism for self-renewal is not yet known, three recent studies shed considerable light on the cell cycle behavior of germ cells, including a support for significant and plastic renewal potential. This review brings together the results of the three recent cell-based studies, places them in the context of previous work, and discusses future perspectives for the field. Developmental Dynamics 236:3343-3357, 2007. (c) 2007 Wiley-Liss, Inc.
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页码：3343 / 3357
页数：15
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