Spirotetronate Polyketides as Leads in Drug Discovery

被引：67

作者：

Lacoske, Michelle H. ^{[1
]}

Theodorakis, Emmanuel A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ANTI-TUMOR ANTIBIOTICS; MARINE VERRUCOSISPORA STRAIN; ATROP-ABYSSOMICIN-C; PETASIS-FERRIER UNION/REARRANGEMENT; AEROCOLONIGENES SUBSP ANTIBIOTICA; PARTIAL STEREOCHEMICAL ASSIGNMENT; ENANTIOSELECTIVE TOTAL-SYNTHESIS; MICROMONOSPORA SP C39217-R109-7; SUBSTITUTED VINYL CARBANIONS; SMALL-MOLECULE INHIBITORS;

D O I：

10.1021/np500757w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures, potent bioactivities, and significant pharmacological potential. This review groups the family members based on structural and biosynthetic considerations and summarizes synthetic and biological studies that aim to elucidate their mode of action and explore their pharmacological potential.

引用

页码：562 / 575

页数：14

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