A decade of surprises for tRNA nuclear-cytoplasmic dynamics

被引：58
|
作者：
Hopper, Anita K. [1 ]
Shaheen, Hussam H. [1 ,2 ]
机构：
[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
[2] Avon Prod, Suffern, NY 10901 USA
来源：
TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 03期
关键词：
D O I：
10.1016/j.tcb.2008.01.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The biosynthesis of tRNA was previously thought to occur solely in the nucleus, with tRNA functioning only in the cytoplasm of eukaryotic cells. However, recent publications have reported that pre-tRNA splicing can occur in the cytoplasm, that aminoacylation can occur in the nucleus and that tRNA can travel in a retrograde direction from the cytoplasm to the nucleus. Moreover, the subcellular distribution of tRNA seems to serve unanticipated functions in diverse processes, including response to nutrient availability, DNA repair and HIV replication.
引用
收藏
页码：98 / 104
页数：7
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