A decade of surprises for tRNA nuclear-cytoplasmic dynamics

被引：58
|
作者：
Hopper, Anita K. [1 ]
Shaheen, Hussam H. [1 ,2 ]
机构：
[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
[2] Avon Prod, Suffern, NY 10901 USA
来源：
TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 03期
关键词：
D O I：
10.1016/j.tcb.2008.01.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The biosynthesis of tRNA was previously thought to occur solely in the nucleus, with tRNA functioning only in the cytoplasm of eukaryotic cells. However, recent publications have reported that pre-tRNA splicing can occur in the cytoplasm, that aminoacylation can occur in the nucleus and that tRNA can travel in a retrograde direction from the cytoplasm to the nucleus. Moreover, the subcellular distribution of tRNA seems to serve unanticipated functions in diverse processes, including response to nutrient availability, DNA repair and HIV replication.
引用
收藏
页码：98 / 104
页数：7
相关论文
共 50 条
  • [1] tRNA Nuclear-cytoplasmic Dynamics and Cell Fate
    Li Sheng
    Zhang Jia-Ning
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 36 (03) : 265 - 268
  • [2] Nuclear-cytoplasmic translocation of tRNA
    Kruse, C
    Hartmann, RK
    Müller, PK
    EXPERIMENTAL CELL RESEARCH, 2001, 262 (01) : 3 - 7
  • [3] Strategies for Investigating Nuclear-Cytoplasmic tRNA Dynamics in Yeast and Mammalian Cells
    Pierce, Jacqueline B.
    Chafe, Shawn C.
    Manoja, B. K. Eswara
    van der Merwe, George
    Mangroo, Dev
    NUCLEAR PORE COMPLEXES AND NUCLEOCYTOPLASMIC TRANSPORT - METHODS, 2014, 122 : 415 - 436
  • [4] Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae
    Murthi, Athulaprabha
    Shaheen, Hussam H.
    Huang, Hsiao-Yun
    Preston, Melanie A.
    Lai, Tsung-Po
    Phizicky, Eric M.
    Hopper, Anita K.
    MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (04) : 639 - 649
  • [5] Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics
    Wu, Jingyan
    Bao, Alicia
    Chatterjee, Kunal
    Wan, Yao
    Hopper, Anita K.
    GENES & DEVELOPMENT, 2015, 29 (24) : 2633 - 2644
  • [6] NUCLEAR-CYTOPLASMIC INTERACTIONS
    SCHJEIDE, OA
    MCCANDLE.RG
    MUNN, R
    NATURE, 1965, 205 (4967) : 156 - &
  • [7] NUCLEAR FUNCTION AND NUCLEAR-CYTOPLASMIC INTERACTIONS
    PRESCOTT, DM
    ANNUAL REVIEW OF PHYSIOLOGY, 1960, 22 : 17 - 44
  • [8] The Tau of Nuclear-Cytoplasmic Transport
    Lester, Evan
    Parker, Roy
    NEURON, 2018, 99 (05) : 869 - 871
  • [9] P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics
    Hurto, Rebecca L.
    Hopper, Anita K.
    RNA, 2011, 17 (05) : 912 - 924
  • [10] Abnormal Microtubule Dynamics Impair the Nuclear-Cytoplasmic Transport in Dementia
    Tripathi, Timir
    Kalita, Jupitara
    ACS CHEMICAL NEUROSCIENCE, 2019, 10 (03): : 1133 - 1134
12345