Inferring genome-scale rearrangement phylogeny and ancestral gene order:: a Drosophila case study

被引：20
|
作者：
Bhutkar, Arjun [1 ,2 ]
Gelbart, William M. [2 ]
Smith, Temple F. [1 ]
机构：
[1] Boston Univ, Biomol Engn Res Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Dept Mol & Cell Biol, Cambridge, MA 02138 USA
来源：
GENOME BIOLOGY | 2007年 / 8卷 / 11期
关键词：
D O I：
10.1186/gb-2007-8-11-r236
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis, and inform speciation studies.
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页数：15
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