Baclofen, a treatment for chronic hiccup

The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in true cases. These cases highlight the present state of knowledge related to hiccup. This discussion focuses on the definition and classification of hiccup, etiologies, postulated theories to explain its function, the few studies performed to date, and non-pharmacologic and pharmacologic treatment. Baclofen appears to be the agent most efficacious in the treatment of chronic hiccup. Its commonest side effect is sedation; insomnia, dizziness, weakness, ataxia, and confusion also can occur. Following regular use, abrupt discontinuation can. lend to withdrawal symptoms, such as seizure, and gradual discontinuation is recommended. J Pain Symptom Manage 1998;16:125-132. (C) U.S. Cancer Pain Relief Committee, 1998.