Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics

被引：3
|
作者：
Sato, Itaru [1 ]
Hirama, Masahiro
机构：
[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan
来源：
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2010年 / 68卷 / 11期
基金：
日本科学技术振兴机构;
关键词：
KEDARCIDIN CHROMOPHORE; MADUROPEPTIN CHROMOPHORE; C-1027; CHROMOPHORE; NEOCARZINOSTATIN CHROMOPHORE; ENANTIOSELECTIVE SYNTHESIS; ARYL ETHER; ABSOLUTE STEREOCHEMISTRY; EFFICIENT CONSTRUCTION; STRUCTURE ELUCIDATION; CARBOXYLIC ESTERS;
D O I：
10.5059/yukigoseikyokaishi.68.1123
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were recently synthesized and the total synthesis of (-)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.
引用
收藏
页码：1123 / 1131
页数：9
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