Advances in mechanisms of asthma, allergy, and immunology in 2011

被引：36

作者：

Boyce, Joshua A. ^{[1
]}

Bochner, Bruce ^{[2
]}

Finkelman, Fred D. ^{[3
]}

Rothenberg, Marc E. ^{[3
]}

机构：

[1] Harvard Univ, Div Rheumatol Immunol & Allergy, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[2] Johns Hopkins Univ, Div Allergy & Clin Immunol, Dept Med, Baltimore, MD USA

[3] Cincinnati Childrens Hosp, Div Allergy & Immunol, Dept Pediat, Med Ctr, Cincinnati, OH USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2012年 / 129卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Galactose-alpha-1,3-galactose; cyclic AMP; calcitonin gene-related peptide; dendritic cell; genome-wide association study; facilitated antigen binding; facilitated antigen presentation; interferon; lipopolysaccharide; toluidine diisothiocyanate; Toll-like receptor; vascular endothelial growth factor; DENDRITIC CELLS; T(H)17 CELLS; IGE; IMMUNOTHERAPY; OMALIZUMAB;

D O I：

10.1016/j.jaci.2011.12.968

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T(H)17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review. (J Allergy Clin Immunol 2012;129:335-41.)

引用

页码：335 / 341

页数：7

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