Role of the promyelocytic leukaemia protein in cell death regulation

被引：30
|
作者：
Salomoni, P. [1 ]
Dvorkina, M. [1 ]
Michod, D. [1 ]
机构：
[1] UCL Canc Inst, Samantha Dickson Brain Canc Unit, London WC1E 6BT, England
来源：
CELL DEATH & DISEASE | 2012年 / 3卷
基金：
英国惠康基金;
关键词：
Snail; HNF4; alpha; miRs-200; miR-34a; stemness; TUMOR-SUPPRESSOR PML; DNA-DAMAGE; NEGATIVE REGULATION; SELF-RENEWAL; APOPTOSIS; AUTOPHAGY; P73; P53; TRAIL; INDUCTION;
D O I：
10.1038/cddis.2011.122
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor a. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation. Cell Death and Disease (2012) 3, e247; doi:10.1038/cddis.2011.122; published online 12 January 2012
引用
收藏
页码：e247 / e247
页数：6
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