Cerebral Small Vessel Disease

被引：220

作者：

Li, Qian ^{[1
,2
]}

Yang, Yang ^{[3
]}

Reis, Cesar ^{[4
]}

Tao, Tao ^{[3
]}

Li, Wanwei ^{[1
,2
]}

Li, Xiaogang ^{[3
]}

Zhang, John H. ^{[4
,5
]}

机构：

[1] Army Med Univ, Affiliated Hosp 3, Dept Pediat, Chongqing, Peoples R China

[2] Army Med Univ, Field Surg Inst, Chongqing, Peoples R China

[3] Southwest Med Univ, Affiliated Hosp, Dept Neurol, Luzhou, Sichuan, Peoples R China

[4] Loma Linda Univ, Sch Med, Dept Physiol & Pharmacol, Loma Linda, CA USA

[5] Loma Linda Univ, Sch Med, Dept Anesthesiol, Loma Linda, CA USA

来源：

CELL TRANSPLANTATION | 2018年 / 27卷 / 12期

关键词：

Cerebral small vessel disease; arteriolosclerosis; cerebral amyloid angiopathy; neuroimaging; MRI; stroke syndrome; dementia; TRANSIENT ISCHEMIC ATTACK; WHITE-MATTER HYPERINTENSITIES; RECENT LACUNAR STROKE; AMYLOID ANGIOPATHY; INTRACEREBRAL HEMORRHAGE; COGNITIVE IMPAIRMENT; MRI CHARACTERISTICS; ALZHEIMER-DISEASE; DIFFUSION TENSOR; BLOOD-FLOW;

D O I：

10.1177/0963689718795148

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The main clinical manifestations of CSVD include stroke, cognitive decline, dementia, psychiatric disorders, abnormal gait, and urinary incontinence. Currently, there are no specific preventive or therapeutic measures to improve this condition. In this review, we will discuss the pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease.

引用

页码：1711 / 1722

页数：12

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