Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss

被引：42
|
作者：
Evidente, VGH
Caviness, JN
Adler, CH
Gwinn-Hardy, KA
Pratley, RE
机构：
[1] Mayo Clin Scottsdale, Dept Neurol, Scottsdale, AZ 85259 USA
[2] Mayo Clin Jacksonville, Jacksonville, FL 32224 USA
[3] Natl Inst Hlth, Phoenix, AZ USA
来源：
MOVEMENT DISORDERS | 2001年 / 16卷 / 05期
关键词：
Parkinson's disease; leptin; satiety; weight loss;
D O I：
10.1002/mds.1165
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger. satiety, fullness, and thirst did not differ between groups. However. the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. ne results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations. (C) 2001 Movement Disorder Society.
引用
收藏
页码：924 / 927
页数：4
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