Water-Compatible Synthesis of 2-Trifluoromethyl-1,3-Dioxanes

被引：1
|
作者：
Becerra-Figueroa, Liliana [1 ]
Tiniakos, Alexander F. [2 ]
Prunet, Joelle [2 ]
Gamba-Sanchez, Diego [1 ]
机构：
[1] Univ Los Andes, Dept Chem, Cra 1 18A-12 Q 305, Bogota 111711, Colombia
[2] Univ Glasgow, Sch Chem, WestCHEM, Joseph Black Bldg,Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 48期
基金：
英国工程与自然科学研究理事会;
关键词：
Water-compatible; Acetals; Oxa-Michael; Trifluoromethyl; Dioxanes; PROTECTED SYN 1,3-DIOLS; INTRAMOLECULAR CONJUGATE ADDITION; OXA-MICHAEL REACTION; DIASTEREOSELECTIVE SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; FLUORINE; TRIFLUOROMETHYLATION; CHEMISTRY;
D O I：
10.1002/ejoc.201801367
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different Michael acceptors. Additionally, the reaction products can be further functionalized, showing an excellent perspective for future applications.
引用
收藏
页码：6929 / 6932
页数：4
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