Highly Diastereoselective Cobalt-Mediated C(sp3)-C(sp2) Cross-Coupling Reactions of Cyclic Halohydrins with (Hetero) Aryl Grignard Reagents

被引:10
|
作者
Hammann, Jeffrey M. [1 ]
Haas, Diana [1 ]
Steib, Andreas K. [1 ]
Knochel, Paul [1 ]
机构
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 10期
关键词
cobalt; diastereoselectivity; cross-coupling; Grignard reagents; arenes; FUNCTIONALIZED ARYLMAGNESIUM; POLYFUNCTIONAL ARYLMAGNESIUM; BR/MG EXCHANGE; LICL;
D O I
10.1055/s-0034-1380407
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The highly diastereoselective cobalt-mediated cross-coupling of cyclic tert-butyldimethylsilyl-protected iodohydrins or bromohydrins with (hetero)arylmagnesium reagents has been expanded further. The method can be applied to a broad range of electron-poor and electron-rich Grignard reagents, furnishing the respective functionalized trans-2-arylcycloalcohols with diastereomeric ratios up to 99:1.
引用
收藏
页码:1461 / 1468
页数:8
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