Cobalt-Catalyzed C(sp2)-C(sp3) Cross-Coupling Reactions of Diarylmanganese Reagents with Secondary Alkyl Iodides

被引：16
|
作者：
Hofmayer, Maximilian S. [1 ]
Hammann, Jeffrey M. [1 ]
Haas, Diana [1 ]
Knochel, Paul [1 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 24期
关键词：
ARYL GRIGNARD-REAGENTS; C-H ACTIVATION; 1,4-COBALT MIGRATION; (HETERO)ARYLZINC REAGENTS; ARYLMAGNESIUM REAGENTS; CYCLIC HALOHYDRINS; ORGANIC HALIDES; BROMIDES; DERIVATIVES; CHLORIDES;
D O I：
10.1021/acs.orglett.6b03349
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A cobalt-catalyzed cross-coupling of diarylmanganese reagents with secondary alkyl iodides using the THF-soluble salt CoCl2. 2LiCl, which leads to the cross-coupling products in up to 92% yield, is reported. High diastereoselectivities can be reached in these cross-couplings (dr up to 99:1). Remarkably, rearrangement of secondary alkyl iodides to unbranched products was not observed in these C-C forming reactions.
引用
收藏
页码：6456 / 6459
页数：4
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