Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend

被引：11

作者：

Mishra, Anupam ^{[1
,2
,3
,4
]}

Sachadeva, Monica ^{[1
,2
,3
,4
]}

Jain, Ankita ^{[1
,2
,3
,4
]}

Shukla, Nimisha Mishra ^{[1
,2
,3
,4
,5
]}

Pandey, Amita ^{[1
,2
,3
,4
,6
]}

机构：

[1] King George Med Univ, Dept Otorhinolaryngol, Lucknow, Uttar Pradesh, India

[2] King George Med Univ, Dept Obstet & Gynaecol, Lucknow, Uttar Pradesh, India

[3] King George Med Univ, Dept Med Genet, Lucknow, Uttar Pradesh, India

[4] Cent Drug Res Inst, Div Endocrinol, Lucknow, Uttar Pradesh, India

[5] John Muir Hosp, Walnut Creek, CA USA

[6] King George Med Univ, Dept Med Genet Obstet & Gynaecol, Lucknow, Uttar Pradesh, India

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2016年 / 37卷 / 04期

关键词：

EPSTEIN-BARR-VIRUS; RECEPTORS; EXPRESSION;

D O I：

10.1016/j.amjoto.2016.03.001

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Juvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of human pappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported. Methods: Clinico-Surgical variables of 6 patients of JNA were included for correlation and their tissue samples were subjected to western blotting (WB), polymerase chain reaction and immunoflorescence to demonstrate a definite association with HPV. In addition 6 control samples (adenoids) underwent WB analysis. Observations: A universal presence of HPV with JNA is novel 'discovery' and has suggested a possibility of a definite association. Only a single case suggested weak infection. None of the controls suggested infection, thus ruling out the presence of HPV in nasopharynx of normal population. Interpretation: With the dawn of this definite association, no specific conclusions can yet be drawn but a whole plethora of questions have emerged with our novel 'discovery'. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：317 / 322

页数：6

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