A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(iv) prodrugs

被引：8
|
作者：
Yao, Houzong [1 ,2 ]
Zhu, Guangyu [1 ,2 ]
机构：
[1] City Univ Hong Kong, Dept Chem, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[2] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
来源：
DALTON TRANSACTIONS | 2022年 / 51卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MECHANISM; DELIVERY; KINETICS; DESIGN; PROBES;
D O I：
10.1039/d2dt00124a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(iv) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(iv) complex in cell extracts.
引用
收藏
页码：5394 / 5398
页数：6
相关论文
共 50 条
  • [21] Platinum(IV) polymeric prodrugs as chemotherapeutic antitumor formulations
    Chhetri, Pratik
    Howell, Bob A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
  • [22] Advanced Platinum-Based Oxygen Reduction Electrocatalysts for Fuel Cells
    Huang, Lei
    Zaman, Shahid
    Tian, Xinlong
    Wang, Zhitong
    Fang, Wensheng
    Xia, Bao Yu
    ACCOUNTS OF CHEMICAL RESEARCH, 2021, 54 (02) : 311 - 322
  • [23] "Turn off-on" fluorescent sensor for platinum drugs-DNA interactions based on quantum dots
    Zhao, Dan
    Li, Jiaotian
    Yang, Tianming
    He, Zhike
    BIOSENSORS & BIOELECTRONICS, 2014, 52 : 29 - 35
  • [24] COMPARISON OF GEFITINIB AND PLATINUM-BASED CHEMOTHERAPY AND ONLY PLATINUM-BASED CHEMOTHERAPY TO TREAT LUNG ADENOCARCINOMA
    Yang, L.
    Fan, J. H.
    Liu, L. L.
    Su, Y.
    Lu, D.
    Huang, J. Y.
    Zhang, H.
    Li, Y.
    Huo, H. D.
    Du, Z. H.
    Liu, G. T.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2018, 32 (03): : 613 - 618
  • [25] Platinum-Based Nanoformulations for Glioblastoma Treatment: The Resurgence of Platinum Drugs?
    Alfonso-Triguero, Paula
    Lorenzo, Julia
    Candiota, Ana Paula
    Arus, Carles
    Ruiz-Molina, Daniel
    Novio, Fernando
    NANOMATERIALS, 2023, 13 (10)
  • [26] Arming anticancer platinum(IV) complexes as prodrugs for targeted chemotherapy
    Ang, Wee Han
    Wong, Daniel Yuan Qiang
    Lim, Jun Han
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [27] Platinum(IV) Prodrugs - A Step Closer to Ehrlich's Vision?
    Kenny, Reece G.
    Chuah, Su Wen
    Crawford, Alanna
    Marmion, Celine J.
    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2017, (12) : 1596 - 1612
  • [28] Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator
    Thiabaud, Gregory
    McCall, Rebecca
    He, Guangan
    Arambula, Jonathan F.
    Siddik, Zahid H.
    Sessler, Jonathan L.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (41) : 12626 - +
  • [29] The effectiveness and safety of platinum-based pemetrexed and platinum-based gemcitabine treatment in patients with malignant pleural mesothelioma
    Ak, Guntulu
    Metintas, Selma
    Akarsu, Muhittin
    Metintas, Muzaffer
    BMC CANCER, 2015, 15
  • [30] Surface structure effects of platinum-based catalysts for oxygen reduction reaction
    Lu, Bang-An
    Tian, Na
    Sun, Shi-Gang
    CURRENT OPINION IN ELECTROCHEMISTRY, 2017, 4 (01) : 76 - 82
12345