A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(iv) prodrugs

被引：8
|
作者：
Yao, Houzong [1 ,2 ]
Zhu, Guangyu [1 ,2 ]
机构：
[1] City Univ Hong Kong, Dept Chem, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[2] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
来源：
DALTON TRANSACTIONS | 2022年 / 51卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MECHANISM; DELIVERY; KINETICS; DESIGN; PROBES;
D O I：
10.1039/d2dt00124a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(iv) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(iv) complex in cell extracts.
引用
收藏
页码：5394 / 5398
页数：6
相关论文
共 50 条
  • [1] Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours
    Fu, Qunfeng
    Zhang, Shuren
    Shen, Siyong
    Gu, Zhi
    Chen, Junyi
    Song, Dongfan
    Sun, Pengwei
    Wang, Chunhong
    Guo, Zhibin
    Xiao, Yunlong
    Gao, Yi Qin
    Guo, Zijian
    Liu, Zhibo
    NATURE BIOMEDICAL ENGINEERING, 2024, 8 (11): : 1425 - 1435
  • [2] A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold
    Montagner, Diego
    Yap, Siew Qi
    Ang, Wee Han
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (45) : 11785 - 11789
  • [3] A Fluorescent probe for investigating the activation of anticancer platinum(IV) prodrugs based on cisplatin scaffold
    Montagner, Diego
    Yap, Siew Qi
    Ang, Wee Han
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S765 - S765
  • [4] Platinum-Based Oxygen Reduction Electrocatalysts
    Wu, Jianbo
    Yang, Hong
    ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (08) : 1848 - 1857
  • [5] Editorial: The role of platinum-based antitumor prodrugs in medicinal inorganic chemistry
    Margiotta, Nicola
    Ravera, Mauro
    Erxleben, Andrea
    FRONTIERS IN CHEMISTRY, 2023, 11
  • [6] Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy
    Zheng, Shunzhe
    Li, Guanting
    Shi, Jianbin
    Liu, Xinying
    Li, Meng
    He, Zhonggui
    Tian, Chutong
    Kamei, Ken-ichiro
    JOURNAL OF CONTROLLED RELEASE, 2023, 361 : 819 - 846
  • [7] Potent Chlorambucil-Platinum(IV) Prodrugs
    Aputen, Angelico D.
    Elias, Maria George
    Gilbert, Jayne
    Sakoff, Jennette A.
    Gordon, Christopher P.
    Scott, Kieran F.
    Aldrich-Wright, Janice R.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (18)
  • [8] Platinum(IV) anticancer prodrugs - hypotheses and facts
    Gibson, Dan
    DALTON TRANSACTIONS, 2016, 45 (33) : 12983 - 12991
  • [9] Rational design of anticancer platinum(IV) prodrugs
    Zhang, Shuren
    Wang, Xiaoyong
    Guo, Zijian
    MEDICINAL CHEMISTRY, 2020, 75 : 149 - 182
  • [10] Investigation of the Inertness to Hydrolysis of Platinum(IV) Prodrugs
    Ritacco, Ida
    Mazzone, Gloria
    Russo, Nino
    Sicilia, Emilia
    INORGANIC CHEMISTRY, 2016, 55 (04) : 1580 - 1586
12345