Nucleic Acid-Based Cell Surface Engineering Strategies and Their Applications

被引:12
|
作者
Wu, Zhongdong [1 ]
Xiao, Mingshu [2 ]
Lai, Wei [2 ]
Sun, Yueyang [2 ]
Li, Li [2 ]
Hu, Zongqian [1 ]
Pei, Hao [2 ]
机构
[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China
[2] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China
来源
ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 05期
基金
美国国家科学基金会;
关键词
cell surface engineering; nucleic acids; DNA nanotechnology; cell surface engineering strategy; biological applications; biosensing; cell-cell interactions; IN-VIVO; DNA NANOSTRUCTURES; FLUORESCENT-PROBE; EXTRACELLULAR-MATRIX; VESICLE FUSION; DRUG-DELIVERY; LIVE CELLS; APTAMERS; RECOGNITION; CANCER;
D O I
10.1021/acsabm.1c01126
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The cell membrane is a biological interface regulating the communications between cells and their environment. The ability to functionalize the cell membrane with molecules or nanomaterials allows us to manipulate cellular behaviors and to expand cellular functions. Due to their unique merits of synthetic accessibility, flexible design, and precise programmability, nucleic acids provide an emerging and promising molecular toolkit for cell surface engineering. In this review, the recent progress in nucleic acid-based cell surface engineering are summarized. We first introduce approaches to nucleic acid-based cell surface engineering, including monovalent and polyvalent surface engineering strategies. Then, the biological applications of nudeic acid-based cell surface engineering in biosensing of extracellular microenvironment, programming cell-cell interactions, and mimicking cellular behaviors are reviewed. Finally, we analyze the current challenges existing in this area and discuss the prospects for the future development.
引用
收藏
页码:1901 / 1915
页数:15
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