Conjugate addition of organocopper reagents in dichloromethane to α,β-unsaturated esters

被引：4
|
作者：
Yang, Jingyue [1 ]
Dudley, Gregory B. [1 ]
机构：
[1] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 44期
关键词：
D O I：
10.1016/j.tetlet.2007.08.105
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Organocopper reagents in conjunction with Lewis acid activators provide greater stability than traditional cuprate reagents while maintaining the reactivity needed for conjugate addition reactions in dichloromethane. Whereas cuprates engage in cross-coupling pathways, organocopper nucleophiles are more selective for conjugate addition. The utility of organocopper reagents in dichloromethane for the conjugate addition to alpha,beta-unsaturated esters is expanded upon herein. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7887 / 7889
页数：3
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