USER-FRIENDLY IMAGE-BASED SEGMENTATION AND ANALYSIS OF CHROMOSOMES

被引：6
|
作者：
Uhlmann, V. [1 ]
Delgado-Gonzalo, R. [1 ]
Unser, M. [1 ]
Michel, P. O. [2 ]
Baldi, L. [2 ]
Wurm, F. M. [2 ]
机构：
[1] Ecole Polytech Fed Lausanne, Biomed Imaging Grp, Lausanne, Switzerland
[2] Ecole Polytech Fed Lausanne, Cellular Biotechnol Lab, Lausanne, Switzerland
来源：
2016 IEEE 13TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI) | 2016年
关键词：
Active contours; segmentation; chromosomes; image analysis; SNAKES;
D O I：
10.1109/ISBI.2016.7493291
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We designed two efficient and user-friendly tools for the segmentation and analysis of images containing chromosomes or, more generally, rod-shaped elements that are spread on microscopic slides. The segmentation tool allows to automatically extract the profile of each chromosome and to sort the collection of profiles in a karyotype image. The analysis tool is interactive and allows to extract quantitative measurements and annotate the relative position of the centromere to the chromosome extremities in a fast and reproducible way. The two methods rely on custom variants of parametric active contours. Both have been designed as user-friendly plug-ins for the open-source software ImageJ.
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页码：395 / 398
页数：4
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