Expedient access to unsymmetrical triarylmethanes through N-heterocyclic carbene catalysed 1,6-conjugate addition of 2-naphthols to para-quinone methides

被引：61
|
作者：
Arde, Panjab [1 ]
Anand, Ramasamy Vijaya [1 ]
机构：
[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sect 81, Manauli Po 140306, Punjab, India
来源：
RSC ADVANCES | 2016年 / 6卷 / 81期
关键词：
FRIEDEL-CRAFTS REACTIONS; CARBON ACID PK(A); AROMATIC-ALDEHYDES; SEQUENTIAL ARYLATION; ASYMMETRIC-SYNTHESIS; CROSS-COUPLINGS; BENZYL HALIDES; ESTERS; ARENES; DIARYLMETHANES;
D O I：
10.1039/c6ra11116e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The utility of N-heterocyclic carbene as a Bronsted base catalyst for the synthesis of functionalised unsymmetrical triarylmethanes from 2-naphthol and para-quinone methides is described. This protocol allows the installation of naphthyl substituents on p-quinone methides through 1,6-conjugate addition to deliver the unsymmetrical triarylmethanes in good to excellent yields. Mild reaction conditions and 100% atom economy make this method synthetically advantageous over the other hitherto known methods.
引用
收藏
页码：77111 / 77115
页数：5
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