Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

被引：100

作者：

Kiem, Hans-Peter ^{[2
,4
,5
]}

Jerome, Keith R. ^{[3
,6
]}

Deeks, Steven G. ^{[7
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 USA

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[4] Univ Washington, Dept Med, Seattle, WA 98109 USA

[5] Univ Washington, Dept Pathol, Seattle, WA 98109 USA

[6] Univ Washington, Dept Lab Med, Seattle, WA 98109 USA

[7] Univ Calif San Francisco, HIV AIDS Program, San Francisco, CA 94110 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 02期

关键词：

BLOOD PROGENITOR CELLS; MARROW REPOPULATING CELLS; IN-VIVO; T-CELLS; MULTILINEAGE HEMATOPOIESIS; EFFICIENT TRANSDUCTION; LENTIVIRAL VECTOR; MURINE MARROW; SELF-RENEWAL; IMMUNODEFICIENCY;

D O I：

10.1016/j.stem.2011.12.015

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a donor lacking the HIV coreceptor, CCR5. Here, we review this and other strategies for HSC-based gene therapy for HIV disease. © 2012 Elsevier Inc.

引用

页码：137 / 147

页数：11

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