Serotonin Reuptake Inhibitors and Risk of Abnormal Bleeding

被引：39
|
作者：
Andrade, Chittaranjan [1 ]
Sharma, Eesha [2 ]
机构：
[1] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India
[2] King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India
来源：
PSYCHIATRIC CLINICS OF NORTH AMERICA | 2016年 / 39卷 / 03期
关键词：
Antidepressant; Serotonin reuptake inhibitor; Selective serotonin reuptake inhibitor; Bleeding; Postpartum hemorrhage; Intracranial hemorrhage; Nonsteroidal anti-inflammatory drugs; Antiplatelet drugs; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POPULATION-BASED COHORT; POSTPARTUM HEMORRHAGE; PREADOLESCENT GIRL; ANTIDEPRESSANTS; METAANALYSIS; STROKE; SERTRALINE; THERAPY; SURGERY;
D O I：
10.1016/j.psc.2016.04.010
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Serotonin reuptake inhibitors (SRIs) increase the risk of abnormal bleeding by lowering platelet serotonin and hence the efficiency of platelet-driven hemostasis; by increasing gastric acidity and possibly gastric ulceration; and by other mechanisms. The upper gastrointestinal tract is the commonest site of SRI-related abnormal bleeding; bleeding at this location may be increased by concurrent nonsteroidal anti-inflammatory drug therapy and by treatment with antiplatelet or anticoagulant drugs. Bleeding at this location may be reduced by concurrent administration of acid-suppressing drugs.
引用
收藏
页码：413 / +
页数：15
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