Digoxin Blocks Ouabain-Induced Hypertension by Preventing Up-Regulation of the Na/Ca Exchanger-1/TRPC6 Ca2+ Signaling Pathway

被引：0
|
作者：
Zulian, Alessandra [1 ]
Pulina, Maria V. [1 ]
Linde, Cristina I. [1 ]
Baryshnikov, Sergey G. [1 ]
Hamlyn, John M. [1 ]
Blaustein, Mordecai P. [1 ]
Golovina, Vera A. [1 ]
机构：
[1] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
来源：
HYPERTENSION | 2010年 / 56卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
引用
收藏
页码：E57 / E57
页数：1
相关论文
共 44 条
  • [1] Signaling mechanisms that link salt retention to hypertension: Endogenous ouabain, the Na+ pump, the Na+/Ca2+ exchanger and TRPC proteins
    Blaustein, Mordecai P.
    Hamlyn, John M.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (12): : 1219 - 1229
  • [2] Role of vascular Na+/Ca2+ exchanger-1 in salt-sensitive hypertension
    Iwamoto, T
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97 : 57P - 57P
  • [3] Effects of a Na+/Ca2+ exchanger inhibitor on pulmonary vein electrical activity and ouabain-induced arrhythmogenicity
    Wongcharoen, Wanwarang
    Chen, Yao-Chang
    Chen, Yi-Jen
    Chang, Che-Ming
    Yeh, Hung-I
    Lin, Cheng-I
    Chen, Shih-Ann
    CARDIOVASCULAR RESEARCH, 2006, 70 (03) : 497 - 508
  • [4] C-Jun mobilizes cytosolic Ca2+ via TRPC6 and Na+/Ca2+ exchanger in uterine artery endothelial cells.
    Zhang, Shen
    Dong, Hui
    Chen, Dong-bao
    BIOLOGY OF REPRODUCTION, 2006, : 79 - 79
  • [5] Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy
    Bai, Yan
    Morgan, Eric E.
    Giovannucci, David R.
    Pierre, Sandrine V.
    Philipson, Kenneth D.
    Askari, Amir
    Liu, Lijun
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2013, 304 (03): : H427 - H435
  • [6] TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca2+/CaMKII signaling pathway
    Li, Junhao
    Zhang, Jiaji
    Zhong, Yunlong
    Xie, Dongge
    Han, Han
    Zhang, Zhongqing
    Liu, Yong
    Li, Shoutian
    CELLULAR SIGNALLING, 2024, 122
  • [7] Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats
    Zulian, Alessandra
    Baryshnikov, Sergey G.
    Linde, Cristina I.
    Hamlyn, John M.
    Ferrari, Patrizia
    Golovina, Vera A.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 299 (03): : H624 - H633
  • [8] The Na+/Ca2+ exchanger-1 mediates nitric oxide-induced cytotoxicity in astrocytes
    Nashida, Tetsuaki
    Kitao, Tatsuya
    Inoue, Yuriko
    Kawasaki, Toshiyuki
    Ago, Yukio
    Takuma, Kazuhiro
    Matsuda, Toshio
    NEUROSCIENCE RESEARCH, 2010, 68 : E242 - E242
  • [9] Cross Talk Between Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/Orai-Containing Channels: Key Players in Arterial Hypertension
    Pulina, Maria V.
    Zulian, A.
    Baryshnikov, Sergey G.
    Linde, Cristina I.
    Karashima, Eiji
    Hamlyn, John M.
    Ferrari, Patrizia
    Blaustein, Mordecai P.
    Golovina, Vera A.
    SODIUM CALCIUM EXCHANGE: A GROWING SPECTRUM OF PATHOPHYSIOLOGICAL IMPLICATIONS, 2013, 961 : 365 - 374
  • [10] Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig
    Shpak, Beni
    Gofman, Yana
    Shpak, Chagit
    Hiller, Reuben
    Boyman, Liron
    Khananshvili, Daniel
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 553 (1-3) : 196 - 204
12345