The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

被引：35

作者：

Tian, Wen ^{[1
,2
]}

Jiang, Shirley Y. ^{[2
]}

Jiang, Xinguo ^{[1
,2
]}

Tamosiuniene, Rasa ^{[1
]}

Kim, Dongeon ^{[2
]}

Guan, Torrey ^{[1
]}

Arsalane, Siham ^{[1
,2
]}

Pasupneti, Shravani ^{[2
]}

Voelkel, Norbert F. ^{[3
]}

Tang, Qizhi ^{[4
]}

Nicolls, Mark R. ^{[1
,2
]}

机构：

[1] VA Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[3] Univ Amsterdam, Med Ctr, Dept Pulm Med, Amsterdam, Netherlands

[4] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

美国国家卫生研究院;

关键词：

regulatory T cell; pulmonary arterial hypertension; sexual dimorphism; right ventricle; estrogen; SEX-DIFFERENCES; FOXP3; EXPRESSION; ESTROGEN; IMMUNE; TREG; HUMAN-HERPESVIRUS-8; PATHOBIOLOGY; AUTOIMMUNITY; PATHOGENESIS; KYNURENINE;

D O I：

10.3389/fimmu.2021.684657

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4(+)CD25(high)FOXP3(+) Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

引用

页数：9

共 50 条

[31] AUTOIMMUNITY AND PULMONARY ARTERIAL HYPERTENSION: THE ROLE OF LEPTIN
Huertas, A.
Montani, D.
Perros, F.
Cohen-Kaminsky, S.
Humbert, M.
INFLAMMATION RESEARCH, 2011, 60 : 184 - 184
[32] The role of rehabilitation in patients with pulmonary arterial hypertension
Eichstaedt, Christina A.
Benjamin, Nicola
Xanthouli, Panagiota
Marra, Alberto M.
Gruenig, Ekkehard
CURRENT OPINION IN PULMONARY MEDICINE, 2019, 25 (05) : 398 - 404
[33] Role of Integrin Signaling in Pulmonary Arterial Hypertension
Lemay, Sarah-eve
Montesinos, Monica S.
Grobs, Yann
Shimauchi, Tsukasa
Bonnet, Sandra Breuils
Martineau, Sandra
Huang, Xinqiang
Dowling, James E.
Lu, Min
Ray, Adrian S.
CIRCULATION, 2021, 144
[34] An Expanding Role of Biomarkers in Pulmonary Arterial Hypertension
Yildiz, Mustafa
Sahin, Alparslan
Behnes, Michael
Akin, Ibrahim
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2017, 18 (06) : 491 - 494
[35] The Role of Echocardiography in the Evaluation of Pulmonary Arterial Hypertension
Pristera, Nicole
Musarra, Ray
Schilz, Robert
Hoit, Brian D.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2016, 33 (01): : 105 - 116
[36] The role of the right ventricle in pulmonary arterial hypertension
Noordegraaf, A. Vonk
Galie, N.
EUROPEAN RESPIRATORY REVIEW, 2011, 20 (122): : 243 - 253
[37] Pulmonary arterial hypertension - The key role of echocardiography
Bossone, E
Bodini, BD
Mazza, A
Allegra, L
CHEST, 2005, 127 (05) : 1836 - 1843
[38] Role of Hypusine Signaling in Pulmonary Arterial Hypertension
Lemay, S.
Grobs, Y.
Orcholski, M.
Shimauchi, T.
Bonnet, L.
Potus, F.
Provencher, S.
Bonnet, S.
Boucherat, O.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
[39] Biglycans role in idiopathic pulmonary arterial hypertension
Radic, N.
Jandl, K.
Redolfi, A. C. Mutgan
Fessler, J.
Schaefer, L.
Kwapiszewska, G.
WIENER KLINISCHE WOCHENSCHRIFT, 2023, 135 (19-20) : 576 - 576
[40] The role of the primary cilium in pulmonary arterial hypertension
Solymosi, Philip
Gallo, Kathleen
Sinn, Katharina
Klepetko, Walter
Kwapiszewska, Grazyna
Preissner, Robert
Kubler, Wolfgang
FASEB JOURNAL, 2021, 35

← 1 2 3 4 5 →