The expression of cyclin E and p53 proteins in human gastric cancer

被引：0
|
作者：
Sakaguchi, T
Watanabe, A
Sawada, H
Yamada, Y
Yamashita, J
Matsuda, M
Tatsumi, M
Nakajima, M
Miwa, T
Hirao, T
Nakano, H
机构：
来源：
PROGRESS IN GASTRIC CANCER RESEARCH 1997: PROCEEDINGS OF THE 2ND INTERNATIONAL GASTRIC CANCER CONGRESS | 1997年
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunohistochemical analysis for cyclin E and p53 proteins was performed among 116 gastric cancer cases. The total cyclin E positive rate was 44.0% (51/116) of all cases and 26 of them showed strongly positive. Strong cyclin E expression was frequently observed in deeply invasive tumors, the cases with lymph node metastasis and advanced stages. Moreover, the incidence of p53 expression was significantly higher in the cyclin E positive tumors. These data suggest that cyclin E expression correlates with p53 expression and may contribute to the progression of gastric cancer.
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页码：547 / 550
页数：4
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