The identity of the transcription+1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis

被引：95
|
作者：
Krasny, Libor [1 ,2 ]
Tiserova, Hana [1 ,2 ]
Jonak, Jiri [1 ,2 ,3 ]
Rejman, Dominik [4 ]
Sanderova, Hana [1 ,2 ]
机构：
[1] Inst Microbiol ASCR, Lab Mol Genet Bacteria, Prague 14220, Czech Republic
[2] Inst Microbiol ASCR, Dept Bacteriol, Prague 14220, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Inst Med Biochem, Prague 12000, Czech Republic
[4] Inst Organ Chem & Biochem ASCR, Lab Med Chem 2, Prague 16637, Czech Republic
来源：
MOLECULAR MICROBIOLOGY | 2008年 / 69卷 / 01期
关键词：
D O I：
10.1111/j.1365-2958.2008.06256.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We identify here a pattern in the transcription start sites (+1A or +1G) of sigma(A)-dependent promoters of genes that are up-/downregulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating nucleoside triphosphate concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation.
引用
收藏
页码：42 / 54
页数：13
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