Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

被引：38
|
作者：
Rombola, Laura [1 ]
Scuteri, Damiana [1 ]
Watanabe, Chizuko [2 ]
Sakurada, Shinobu [2 ]
Hamamura, Kengo [3 ]
Sakurada, Tsukasa [3 ]
Tonin, Paolo [4 ]
Corasaniti, Maria Tiziana [5 ]
Bagetta, Giacinto [1 ]
Morrone, Luigi Antonio [1 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth Sci & Nutr, Preclin & Translat Pharmacol, I-87036 Arcavacata Di Rende, Italy
[2] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan
[3] Daiichi Coll Pharmaceut Sci, Dept Pharmacol Fukuoka 1, Fukuoka 8158511, Japan
[4] S Anna Inst, Reg Ctr Serious Brain Injuries, I-88900 Crotone, Italy
[5] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 07期
关键词：
aromatherapy; bergamot essential oil; serotonin neurotransmission; anxiety and motor behavioral tests; MONOSODIUM GLUTAMATE; OPEN-FIELD; PLUS-MAZE; ANXIETY; RAT; SEROTONIN; BEHAVIOR; ANTAGONIST; DEPRESSION; MICE;
D O I：
10.3390/ijms21072597
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((+/-)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.
引用
收藏
页数：14
相关论文
共 50 条
  • [41] 5-HT1A receptor blockade reverses GABAA receptor α3 subunit-mediated anxiolytic effects on stress-induced hyperthermia
    Christiaan H. Vinkers
    Ruud van Oorschot
    S. Mechiel Korte
    Berend Olivier
    Lucianne Groenink
    Psychopharmacology, 2010, 211 : 123 - 130
  • [42] Development of 5-HT1A receptor antagonists
    Routledge, C
    BEHAVIOURAL BRAIN RESEARCH, 1996, 73 (1-2) : 153 - 156
  • [43] 5-HT1A receptor blockade reverses GABAA receptor α3 subunit-mediated anxiolytic effects on stress-induced hyperthermia
    Vinkers, Christiaan H.
    van Oorschot, Ruud
    Korte, S. Mechiel
    Olivier, Berend
    Groenink, Lucianne
    PSYCHOPHARMACOLOGY, 2010, 211 (02) : 123 - 130
  • [44] LABELING OF THE 5-HT1A RECEPTOR SUBTYPE
    SHIH, JC
    ASARCH, KB
    RANSOM, R
    PSYCHOPHARMACOLOGY BULLETIN, 1986, 22 (03) : 818 - 824
  • [45] Recent 5-HT1A receptor agonists
    Gurwitz, D
    DRUG DISCOVERY TODAY, 1999, 4 (03) : 142 - 143
  • [46] The 5-HT1A receptor: Signaling to behavior
    Albert, Paul R.
    Vahid-Ansari, Faranak
    BIOCHIMIE, 2019, 161 : 34 - 45
  • [47] Effects of the 5-HT1A receptor agonist flesinoxan in panic disorder
    vanVliet, IM
    Westenberg, HGM
    denBoer, JA
    PSYCHOPHARMACOLOGY, 1996, 127 (02) : 174 - 180
  • [48] Separate and combined effects of fluoxetine and a 5-HT1A receptor agonist or antagonist on 5-HT1A and 5-HT1B autoreceptor activity in the rat brain
    Shalom, G
    Gur, E
    Van de Kar, LD
    Lerer, B
    Newman, ME
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2004, 14 : S15 - S16
  • [49] Effects of a glucocorticoid receptor antagonist and an SSRI on 5-HT transporter binding and 5-HT1A receptor mRNA
    Johnson, D. A.
    Grant, E. J.
    Ingram, C. D.
    Gartside, S. E.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 : S255 - S255
  • [50] Novel antipsychotic agents with 5-HT1A agonist properties:: Role of 5-HT1A receptor activation in attenuation of catalepsy induction in rats
    Kleven, MS
    Barret-Grévoz, C
    Slot, LB
    Newman-Tancredi, A
    NEUROPHARMACOLOGY, 2005, 49 (02) : 135 - 143
12345