In silico predictive tools for screening hERG activity in early drug discovery

被引：0

作者：

Gavaghan, Claire ^{[1
]}

Belda, Ignasi ^{[1
]}

Carlsson, Lars ^{[1
]}

Donner, Henrik ^{[1
]}

Boyer, Scott ^{[1
]}

机构：

[1] AstraZeneca R&D, Molndal 43183, Sweden

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2007年 / 20卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

140

引用

页码：2018 / 2018

页数：1

共 50 条

[21] Development of hydrolytic stability screening methods for early drug discovery with high differentiation and predictive power
Wang, Jianyan
Ottosson, Jenny
Tentarelli, Sharon
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 233
[22] Early identification of hERG liability in drug discovery programs by automated patch clamp
Danker, Timm
Moeller, Clemens
FRONTIERS IN PHARMACOLOGY, 2014, 5
[23] Virtual combinatorial chemistry and in silico screening: Efficient tools for lead structure discovery?
Langer, T
Wolber, G
PURE AND APPLIED CHEMISTRY, 2004, 76 (05) : 991 - 996
[24] Crystallography, NMR and virtual screening: Integrated tools for drug discovery
Muchmore, SW
Hajduk, PJ
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2003, 6 (04) : 544 - 549
[25] Invertebrate animal models of diseases as screening tools in drug discovery
Segalat, Laurent
ACS CHEMICAL BIOLOGY, 2007, 2 (04) : 231 - 236
[26] In silico pharmacology for drug discovery:: methods for virtual ligand screening and profiling
Ekins, S.
Mestres, J.
Testa, B.
BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (01) : 9 - 20
[27] Role of ADME characteristics in drug discovery and their in silico evaluation:: In silico screening of chemicals for their metabolic stability
Gombar, VK
Silver, IS
Zhao, ZY
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (11) : 1205 - 1225
[28] Role of In Silico Tools in Gene Discovery
Bing Yu
Molecular Biotechnology, 2009, 41 : 296 - 306
[29] Role of In Silico Tools in Gene Discovery
Yu, Bing
MOLECULAR BIOTECHNOLOGY, 2009, 41 (03) : 296 - 306
[30] EXPLOITING SECONDARY PHARMACOLOGY IN DRUG DISCOVERY: IN SILICO GUIDED WET LABORATORY SCREENING OF GENERIC DRUGS FOR ANTIMALARIAL ACTIVITY
Bello, S.
Aminu, C.
AbdulMajeed, Y.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 161 - 161

← 1 2 3 4 5 →