Tyrosinase inhibitors and sesquiterpene diglyclosides from Guioa villosa

被引：20
|
作者：
Magid, Abdulmagid Alabdul [1 ]
Voutquenne-Nazabadioko, Laurence [1 ]
Bontemps, Geolfroy [1 ]
Litaudon, Marc [2 ]
Lavaud, Catherine [1 ]
机构：
[1] Univ Reims, Biomol IFR53, CNRS, Lab Pharmacognosie,FRE 2715, F-51687 Reims 2, France
[2] CNRS, Inst Chim Subst Nat, Gif Sur Yvette, France
来源：
PLANTA MEDICA | 2008年 / 74卷 / 01期
关键词：
Guioa villosa; Sapindaceae; terpenoids; tyrosinase inhibitor;
D O I：
10.1055/s-2007-993780
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides (1-7), five flavonoids (8-12), one trimeric proanthocyanidin (13), two triterpenes (14 and 15), and one cerebroside (16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G (1-3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin (14), lupeol (15) and soyacerebroside I (16) demonstrated a potent tyrosinase inhibitory activity.
引用
收藏
页码：55 / 60
页数：6
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