Copper-Catalyzed Double Decarboxylative Coupling Reactions of Alkynyl Carboxylic Acid and Glyoxylic Acid: Synthesis of Propargyl Amines and Imidazopyridines

被引：27

作者：

Choi, Jinseop ^{[1
]}

Lim, Jeongah ^{[1
]}

Irudayanathan, Francis Mariaraj ^{[1
]}

Kim, Han-Sung ^{[1
]}

Park, Jaerim ^{[1
]}

Yu, Su Been ^{[1
]}

Jang, Yuna ^{[1
]}

Raja, Gabriel Charles Edwin ^{[1
]}

Nam, Kye Chun ^{[1
]}

Kim, Jimin ^{[1
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

alkynes; C-C coupling; copper; decarboxylation; multicomponent reactions; C-H ACTIVATION; ONE-POT SYNTHESIS; ARYL HALIDES; PROPIOLIC ACID; BIARYL SYNTHESIS; ALDEHYDE; CYCLIZATION; HYDROACYLATION; FORMALDEHYDE; DERIVATIVES;

D O I：

10.1002/ajoc.201600109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of alkynyl carboxylic acids, glyoxylic acid derivatives, and amines in the presence of a copper catalyst afforded the corresponding propargyl amines in good yields. The alkynyl carboxylic acid of this coupling reaction shows similar reactivity to that of a terminal alkyne, and the reactivity of the glyoxylic acid is almost identical to that of an aldehyde. When 2-aminopyridine was employed as the amine source, imidazopyridine derivatives were formed in good yields.

引用

页码：770 / 777

页数：8

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