A New Model for Simulating Spindle Asymmetric Division Mediated by Cortical Actin

Cell division is an important and fundamental process which is contributed to cell proliferation and differentiation. For mammalian, female meiotic divisions are typically asymmetric, generating two kinds of daughter cells with unequal size. This mechanism is essential to retain sufficient storage material for the development of embryo after fertilization. In order to achieve asymmetric division, the most crucial procedure is the migration of spindle from the center to cortex in meiosis I. In this paper, we used a set of PDEs with two reacting and diffusing chemical morphogens and adding another substance to represent cortex actin to investigate the mechanism of spindle movement in meiosis I. According to our simulation result, our hypothesis showed good consistency with real division process.