This paper describes an optimal bio-inspired PID controller for accurate steering management of the Autonomous Underwater Vehicle system (AUV). To achieve precise control performance, a PM controller is designed, and its gain parameters K-p, K-i, K-d are tuned by applying Simulated Annealing (SA), Genetic Algorithm (GA) and Moth-Flame Optimization Algorithm (MFO). The experimental response corresponding to the unit step and square input waveform for these proposed nature-inspired optimization algorithms were obtained. The response characteristics like overshoot, rise time, settling time and performances index ITAE were calculated and compared. The experimental results show that MFO-PID is highly efficient, followed by GA and SA, respectively.