Expression of steroidogenic acute regulatory protein and its regulation by interferon-gamma in rat corpus luteum

被引：6
|
作者：
Gao, HJ [1 ]
Chen, XL [1 ]
Shi, L [1 ]
Liu, YX [1 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2000年 / 45卷 / 23期
基金：
中国国家自然科学基金;
关键词：
corpus luteum; StAR; in situ hybridization; immunohistochemistry; IFN gamma;
D O I：
10.1007/BF02886320
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The steroidogenic acute regulatory protein (StAR) is the key regulatory protein of steroidogenesis, De novo synthesis of StAR protein is required for intramitochondrial translocation of cholesterol to the cytochrome P450 side chain cleavage enzyme which is located on the matrix side of the inner mitochondrial membrane. This is the rate-limiting step of steroid biosynthesis, Using in situ hybridization and immunohistochemistry we studied StAR expression in various stages of the corpora luteal and its regulation by interferon-gamma (IFN gamma) in the adult pseudopregnant rat. The results indicated that expression of StAR in the corpora luteal was correlated with progesteron production and IFN gamma was capable of inhibiting its expression.
引用
收藏
页码：2152 / 2157
页数：6
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