Zinc chloride catalyzed three-component Ugi reaction: synthesis of N-cyclohexyl-2-(2-hydroxyphenylamino)acetamide derivatives

被引：35

作者：

Shaabani, Ahmad ^{[1
]}

Keshipour, Sajjad ^{[1
]}

Shaabani, Shabnam ^{[1
]}

Mahyari, Mojtaba ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, GC, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 13期

关键词：

Three-component Ugi reaction; Zinc chloride; Acetamide; Isocyanide; AMINO-ACID AMIDES; ANTICONVULSANT ACTIVITY; CONDENSATION REACTION; MULTICOMPONENT REACTIONS; ISOCYANIDES;

D O I：

10.1016/j.tetlet.2012.01.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ability of zinc chloride as a catalyst to promote the three-component Ugi reaction of 2-aminophenols, aliphatic or aromatic aldehydes, and cyclohexyl isocyanide in methanol at room temperature is described. The N-cyclohexyl-2-(2-hydroxyphenylamino) amide products are obtained in high yields. When N,N-dimethylformamide dimethyl acetal and triethyl orthoformate, as two new components of the three-component Ugi reaction are used instead of the aldehyde the reaction gives N-cyclohexyl-2-(dimethylamino)-2-(2-hydroxyphenylamino)acetamide and N-cyclohexyl-2-(2-hydroxyphenylamino)-2-ethoxyacetamide derivatives, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1641 / 1644

页数：4

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