Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton

被引：44
|
作者：
Pu, JX
Xiao, WL
Lu, Y
Li, RT
Li, HM
Zhang, L
Huang, SX
Li, X
Zhao, OS
Zheng, QT
Sun, HD [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 22期
关键词：
D O I：
10.1021/ol052161j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel triterpene dilactones with an unprecedented rearranged hexacyclic skeleton, kadlongilactones A (1) and B (2), have been isolated from the leaves and stems of Kadsura longipedunculata Finet et Gagnep (Schisandraceae). Their structures were established by comprehensive 1D and 2D NMR spectroscopic analysis, coupled with single-crystal X-ray crystallographic diffraction. Compounds 1 and 2 exerted significant inhibitory effects against human tumor K562 cells with IC50 = 1.40 and 1.71 mu g/mL, respectively.
引用
收藏
页码：5079 / 5082
页数：4
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