Serum levels of BDNF are associated with craving in opiate-dependent patients

被引：48

作者：

Heberlein, Annemarie ^{[1
,2
]}

Duersteler-MacFarland, Kenneth M. ^{[3
]}

Lenz, Bernd ^{[2
]}

Frieling, Helge ^{[1
,2
]}

Groesch, Michael ^{[1
,4
]}

Boensch, Dominikus ^{[5
]}

Kornhuber, Johannes ^{[2
]}

Wiesbeck, Gerhard A. ^{[3
]}

Bleich, Stefan ^{[1
,2
]}

Hillemacher, Thomas ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Addict Res Ctr, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany

[2] Univ Hosp Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[3] Univ Basel, Hosp Psychiat, Div Subst Use Disorders, Basel, Switzerland

[4] Univ Hosp Erlangen, Dept Pediat, Erlangen, Germany

[5] Psychiat Krankenhaus Rickling, Rickling, Germany

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2011年 / 25卷 / 11期

关键词：

BDNF; craving; GDNF; neurotrophic growth factors; opiate dependence; opiate maintenance; NEUROTROPHIC FACTOR; MESSENGER-RNAS; KNOCKOUT MICE; BRAIN; DOPAMINE; GDNF; WITHDRAWAL; NEURONS; ABUSE; RELAPSE;

D O I：

10.1177/0269881111411332

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are involved in the modulation of addictive behaviour. We investigated alterations in serum levels of BDNF and GDNF in opiate-dependent patients (28 males) who received diacetylmorphine treatment within a structured opiate maintenance programme. BDNF (T = 2.735, p = 0.009) serum levels were significantly increased in the opiate-dependent patients as compared with healthy controls (21 males), whereas GDNF serum levels (T = 1.425, p = 0.162) did not differ significantly from GDNF serum levels of the healthy controls. BDNF serum levels were significantly associated with craving for heroin (measured by the Heroin Craving Questionnaire (r = 0.420, p = 0.029) and by the General Craving Scale (r = 0.457, p = 0.016), whereas GDNF serum levels were not associated with psychometric dimensions of heroin craving. In conclusion, our results show a positive association between BDNF serum levels and opiate craving in opiate-dependent patients.

引用

页码：1480 / 1484

页数：5

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