Serum levels of BDNF are associated with craving in opiate-dependent patients

被引：49
|
作者：
Heberlein, Annemarie [1 ,2 ]
Duersteler-MacFarland, Kenneth M. [3 ]
Lenz, Bernd [2 ]
Frieling, Helge [1 ,2 ]
Groesch, Michael [1 ,4 ]
Boensch, Dominikus [5 ]
Kornhuber, Johannes [2 ]
Wiesbeck, Gerhard A. [3 ]
Bleich, Stefan [1 ,2 ]
Hillemacher, Thomas [1 ,2 ]
机构：
[1] Hannover Med Sch, Addict Res Ctr, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany
[2] Univ Hosp Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
[3] Univ Basel, Hosp Psychiat, Div Subst Use Disorders, Basel, Switzerland
[4] Univ Hosp Erlangen, Dept Pediat, Erlangen, Germany
[5] Psychiat Krankenhaus Rickling, Rickling, Germany
来源：
JOURNAL OF PSYCHOPHARMACOLOGY | 2011年 / 25卷 / 11期
关键词：
BDNF; craving; GDNF; neurotrophic growth factors; opiate dependence; opiate maintenance; NEUROTROPHIC FACTOR; MESSENGER-RNAS; KNOCKOUT MICE; BRAIN; DOPAMINE; GDNF; WITHDRAWAL; NEURONS; ABUSE; RELAPSE;
D O I：
10.1177/0269881111411332
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are involved in the modulation of addictive behaviour. We investigated alterations in serum levels of BDNF and GDNF in opiate-dependent patients (28 males) who received diacetylmorphine treatment within a structured opiate maintenance programme. BDNF (T = 2.735, p = 0.009) serum levels were significantly increased in the opiate-dependent patients as compared with healthy controls (21 males), whereas GDNF serum levels (T = 1.425, p = 0.162) did not differ significantly from GDNF serum levels of the healthy controls. BDNF serum levels were significantly associated with craving for heroin (measured by the Heroin Craving Questionnaire (r = 0.420, p = 0.029) and by the General Craving Scale (r = 0.457, p = 0.016), whereas GDNF serum levels were not associated with psychometric dimensions of heroin craving. In conclusion, our results show a positive association between BDNF serum levels and opiate craving in opiate-dependent patients.
引用
收藏
页码：1480 / 1484
页数：5
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