Diastereoselective synthesis of anti-3-hydroxy-2-trifluoromethyl carboxylic acids

被引：12
|
作者：
Ramachandran, P. Veeraraghavan [1 ]
Otoo, Barnabas [1 ]
Chanda, Prem B. [1 ]
机构：
[1] Purdue Univ, Dept Chem, Herbert C Brown Ctr Borane Res, W Lafayette, IN 47907 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期
关键词：
Aldol reaction; Diastereoselective; Trifluoromethyl; 3,3,3-Trifluoropropanoic acid; B-Chlorodicyclohexylborane; BETA-LACTONES; ENOLBORATION; TRIFLUOROMETHYLATION; ALDOLIZATION; TEMPERATURE; REAGENT; SOLVENT;
D O I：
10.1016/j.tetlet.2014.12.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Unlike the hydrocarbon analogs, this first report of enolboration-aldolization of 3,3,3-trifluoropropanoic acid provides essentially pure anti-diastereomers of alpha-trifluoromethyl-beta-hydroxy carboxylic acids in 77-90% yields. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：3019 / 3022
页数：4
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