Diastereoselective synthesis of anti-3-hydroxy-2-trifluoromethyl carboxylic acids

被引：12

作者：

Ramachandran, P. Veeraraghavan ^{[1
]}

Otoo, Barnabas ^{[1
]}

Chanda, Prem B. ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, Herbert C Brown Ctr Borane Res, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期

关键词：

Aldol reaction; Diastereoselective; Trifluoromethyl; 3,3,3-Trifluoropropanoic acid; B-Chlorodicyclohexylborane; BETA-LACTONES; ENOLBORATION; TRIFLUOROMETHYLATION; ALDOLIZATION; TEMPERATURE; REAGENT; SOLVENT;

D O I：

10.1016/j.tetlet.2014.12.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unlike the hydrocarbon analogs, this first report of enolboration-aldolization of 3,3,3-trifluoropropanoic acid provides essentially pure anti-diastereomers of alpha-trifluoromethyl-beta-hydroxy carboxylic acids in 77-90% yields. (C) 2015 Published by Elsevier Ltd.

引用

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页码：3019 / 3022

页数：4

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