Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

被引：160

作者：

Sohn, Jong-Woo ^{[1
]}

Xu, Yong ^{[1
,3
]}

Jones, Juli E. ^{[4
]}

Wickman, Kevin ^{[5
]}

Williams, Kevin W. ^{[1
]}

Elmquist, Joel K. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[3] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[4] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[5] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

NEURON | 2011年 / 71卷 / 03期

关键词：

ENERGY HOMEOSTASIS REGULATION; GATED POTASSIUM CHANNELS; RECTIFYING K+ CHANNELS; MELANOCORTIN PATHWAYS; AGRP NEURONS; GLUCOSE-HOMEOSTASIS; D-FENFLURAMINE; POMC NEURONS; FOOD-INTAKE; I-KACH;

D O I：

10.1016/j.neuron.2011.06.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.

引用

页码：488 / 497

页数：10

共 26 条

[21] Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes
Muslikhov, E. R.
Sukhanova, I. F.
Avdonin, P. V.
BIOCHEMISTRY-MOSCOW, 2014, 79 (05) : 435 - 439
[22] Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes
E. R. Muslikhov
I. F. Sukhanova
P. V. Avdonin
Biochemistry (Moscow), 2014, 79 : 435 - 439
[23] A Central Serotonin 2C Receptor Pathway Regulates Gastrointestinal Motor Activity via Ghrelin-Neuropeptide Y Signaling, But Does Not Require Downstream Activation of Melanocortin 3/4 Receptors in Rats
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[24] Serotonin (5-HT)2A/2C receptor agonist 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride improves detrusor sphincter dyssynergia by inhibiting L-type voltage-gated calcium channels in spinal cord injured rats
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Li, Mingzhuo
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CNS NEUROSCIENCE & THERAPEUTICS, 2024, 30 (08)
[25] On the paper by E. R. Muslikhov, I. F. Sukhanova, and P. V. Avdonin entitled “Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes” published in Biochemistry (Moscow), Vol. 79, No. 5, pp. 435–439 (2014)
Orison O. Woolcott
Md. Shahidul Islam
Biochemistry (Moscow), 2014, 79 : 845 - 846
[26] On the paper by E. R. Muslikhov, I. F. Sukhanova, and P. V. Avdonin entitled "Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes" published in Biochemistry (Moscow), Vol. 79, No. 5, pp. 435-439 (2014)
Woolcott, Orison O.
Islam, Md. Shahidul
BIOCHEMISTRY-MOSCOW, 2014, 79 (08) : 845 - 846

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