Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

被引：160
|
作者：
Sohn, Jong-Woo [1 ]
Xu, Yong [1 ,3 ]
Jones, Juli E. [4 ]
Wickman, Kevin [5 ]
Williams, Kevin W. [1 ]
Elmquist, Joel K. [1 ,2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
[3] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA
[4] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[5] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA
来源：
NEURON | 2011年 / 71卷 / 03期
关键词：
ENERGY HOMEOSTASIS REGULATION; GATED POTASSIUM CHANNELS; RECTIFYING K+ CHANNELS; MELANOCORTIN PATHWAYS; AGRP NEURONS; GLUCOSE-HOMEOSTASIS; D-FENFLURAMINE; POMC NEURONS; FOOD-INTAKE; I-KACH;
D O I：
10.1016/j.neuron.2011.06.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.
引用
收藏
页码：488 / 497
页数：10
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