The application of stratified medicine to dementia care

被引:2
|
作者
Sidhom, Emad [1 ]
O'Brien, John [2 ,3 ,4 ,5 ]
Underwood, Benjamin R. [6 ,7 ]
机构
[1] Univ Cambridge, Dept Clin Neurosci, Cambridge, England
[2] Univ Cambridge, Old Age Psychiat, Cambridge, England
[3] Univ Cambridge, Dept Psychiat, Cambridge, England
[4] Acad Med Sci, London, England
[5] NIHR Natl Specialty Lead Dementia, London, England
[6] Cambridge & Peterborough NHS Fdn Trust, Cambridge, England
[7] Dementia Clin Lead NIHR Clin Res Network CRN, NIHR Clin Res Network CRN, Windsor Res Unit Cambridge, London, England
关键词
Dementia; stratified medicine; neurodegenerative disorders; personalised medicine; genetics; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; TYPE-4; ALLELE; INHIBITION; DONEPEZIL; EFFICACY; THERAPY; GENE;
D O I
10.1192/bja.2020.28
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Stratified medicine has been successfully used in many areas of medicine, perhaps most notably oncology. There is now both a growing evidence base and mounting enthusiasm, supported at a governmental level and across industry, academia and clinical medicine, to apply this approach to neurodegenerative illnesses, including dementia, as these provide the greatest clinical and social challenge of our times. In this article we consider definitions of stratified medicine, look at its application in other medical specialties, review the national context in the UK and consider the current state, future potential and specific considerations of applying stratified medicine to dementia.
引用
收藏
页码:245 / 252
页数:8
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