Folate and homocysteine metabolism: Therapeutic targets cardiovascular and neurodegenerative disorders

被引:28
|
作者
Mattson, MP [1 ]
Haberman, F [1 ]
机构
[1] NIA, Gerontol Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA
关键词
Alzheimer's disease; apoptosis; atherosclerosis; dietary folic acid; Parkinson's disease; schizophrenia; stem cells;
D O I
10.2174/0929867033456864
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.
引用
收藏
页码:1923 / 1929
页数:7
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