N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition

被引：0
|
作者：
Chinthaginjala, Srinivasulu [1 ]
Alavandimat, Nanda H. [1 ]
Umesha, Vathsala [1 ]
Sureshbabu, Vommina V. [1 ]
机构：
[1] Bangalore Univ, Dept Chem, Peptide Res Lab, Bengaluru, India
来源：
SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 19期
关键词：
N-bromosuccinimide; N-beta-protected amino alcohols; N-beta-protected amino bromides; ALKYL CHLORIDES; MEDICINAL CHEMISTRY; CARBOXYLIC-ACIDS; ALCOHOLS; CONVERSION; WITTIG; CARBON; STEREOCHEMISTRY; TRANSFORMATION; HALOGENATION;
D O I：
10.1080/00397911.2021.1955270
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and facile method has been developed for the synthesis of chiral beta-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of beta-amino alcohols in excellent yields under mild conditions without any detectable racemization.
引用
收藏
页码：2975 / 2983
页数：9
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